Article
The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation.
Cellular immunology - 1 Jul 1994
Rosenblatt N, Hartmann K U, Loor F
Abstract excerpt
Mice homozygous for either the generalized lymphoproliferative disease (gld) or the lymphoproliferation (lpr) nonallelic mutations develop similar syndromes combining systemic autoimmunity and lymphoproliferative disease. Though essentially recessive, the lpr and gld mutations may be expressed in...
Topics
- Animals
- Antibodies, Antinuclear
- Autoimmune Diseases
- Female
- Heterozygote
- Immunoglobulin Isotypes
- Lymph Nodes
- Lymphoproliferative Disorders
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Phenotype
- Spleen