Comparison of prospective and retrospective methods for haplotype inference in case-control studies.

Abstract excerpt

We compare bias and power of three methods for haplotype inference on disease risk using unphased genotype data from a case-control study. We examine the prospective score test of Schaid et al., a novel modification of the prospective estimating equations of Zhao et al. and the retrospective likelihood of Epstein and Satten. We find that all three approaches are roughly comparable when the haplotype effect on...

Topics

• Algorithms
• Case-Control Studies
• Computer Simulation
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Humans
• Models, Genetic
• Models, Statistical
• Polymorphism, Single Nucleotide
• Prospective Studies
• Retrospective Studies
• Risk Factors