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Article

Retrospective likelihood-based methods for analyzing case-cohort genetic association studies.

Biometrics - 1 Dec 2015

Shen Yuanyuan, Cai Tianxi, Chen Yu, Yang Ying, Chen Jinbo

Abstract excerpt

The case cohort (CCH) design is a cost-effective design for assessing genetic susceptibility with time-to-event data especially when the event rate is low. In this work, we propose a powerful pseudo-score test for assessing the association between a single nucleotide polymorphism (SNP) and the event time under the CCH design. The pseudo-score is derived from a pseudo-likelihood which is an estimated retrospective...

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Identifiers

PMID: 26177343
DOI: 10.1111/biom.12342
PMCID: PMC4751872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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