Article
Efficient association study design via power-optimized tag SNP selection.
Annals of human genetics - 1 Nov 2008
Han B, Kang H M, Seo M S, Zaitlen N, Eskin E
Abstract excerpt
Discovering statistical correlation between causal genetic variation and clinical traits through association studies is an important method for identifying the genetic basis of human diseases. Since fully resequencing a cohort is prohibitively costly, genetic association studies take advantage of local correlation structure (or linkage disequilibrium) between single nucleotide polymorphisms (SNPs) by selecting a...
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