Article
Power to detect risk alleles using genome-wide tag SNP panels.
PLoS genetics - 1 Oct 2007
Eberle Michael A, Ng Pauline C, Kuhn Kenneth, Zhou Lixin, Peiffer Daniel A, Galver Luana, Viaud-Martinez Karine A, Lawley Cynthia Taylor, Gunderson Kevin L, Shen Richard, Murray Sarah S
Abstract excerpt
Advances in high-throughput genotyping and the International HapMap Project have enabled association studies at the whole-genome level. We have constructed whole-genome genotyping panels of over 550,000 (HumanHap550) and 650,000 (HumanHap650Y) SNP loci by choosing tag SNPs from all populations genotyped by the International HapMap Project. These panels also contain additional SNP content in regions that have...
Topics
- Alleles
- Genome, Human
- Haploidy
- Humans
- Polymorphism, Single Nucleotide
- Risk Factors
