Article
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.
American journal of human genetics - 1 Jan 2004
Carlson Christopher S, Eberle Michael A, Rieder Mark J, Yi Qian, Kruglyak Leonid, Nickerson Deborah A
Abstract excerpt
Common genetic polymorphisms may explain a portion of the heritable risk for common diseases. Within candidate genes, the number of common polymorphisms is finite, but direct assay of all existing common polymorphism is inefficient, because genotypes at many of these sites are strongly correlated...
Topics
- Algorithms
- Black People
- Genetic Diseases, Inborn
- Homozygote
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- United States
- White People
- Black or African American