Article
Marker selection for genetic case-control association studies.
Nature protocols - 1 Jan 2009
Pettersson Fredrik H, Anderson Carl A, Clarke Geraldine M, Barrett Jeffrey C, Cardon Lon R, Morris Andrew P, Zondervan Krina T
Abstract excerpt
Association studies can focus on candidate gene(s), a particular genomic region, or adopt a genome-wide association approach, each of which has implications for marker selection. The strategy for marker selection will affect the statistical power of the study to detect a disease association and is a crucial element of study design. The abundant single nucleotide polymorphisms (SNPs) are the markers of choice in...
Topics
- Case-Control Studies
- Genetic Markers
- Genome, Human
- Genome-Wide Association Study
- Genomics
- Genotype
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- Software