Article
Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia.
PloS one - 5 Aug 2009
Pastorino Roberta, Menni Cristina, Barca Monserrata, Foco Luisa, Saddi Valeria, Gazzaniga Giovanna, Ferrai Raffaela, Mascaretti Luca, Dudbridge Frank, Berzuini Carlo, Murgia Salvatore Bruno, Piras Maria Luisa, Ticca Anna, Bitti Pier Paolo, Bernardinelli Luisa
Abstract excerpt
The human leukocyte antigen (HLA) complex on chromosome 6p21 has been unambiguously associated with multiple sclerosis (MS). The complex features of the HLA region, especially its high genic content, extreme polymorphism, and extensive linkage disequilibrium, has prevented to resolve the nature of HLA association in MS. We performed a family based association study on the isolated population of the Nuoro province...
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