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Article

DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population.

Human molecular genetics - 1 Aug 1998

Marrosu M G, Murru M R, Costa G, Murru R, Muntoni F, Cucca F

Abstract excerpt

Multiple sclerosis (MS) is a common neurological disease caused by genetic and environmental factors. Previous genetic analyses have suggested that theMHC/HLA region on chromosome 6p21 contains an MS-predisposing component. Which of the many genes present in this region is primarily responsible for disease susceptibility is still an open issue. In this study, we evaluated, in a large cohort of MS families from...

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PMID: 9668164
DOI: 10.1093/hmg/7.8.1235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population.PMID 9668164Read ↗

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Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia.Semantic proximity Read ↗

HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia.Semantic proximity Read ↗

Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia.Semantic proximity Read ↗

The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone.Semantic proximity Read ↗

Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population.Semantic proximity Read ↗

Lack of evidence for a role of the myelin basic protein gene in multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

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Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population.Semantic proximity Read ↗

HLA-DQB1 genotype in Sardinian multiple sclerosis: evidence for a key role of DQB1 *0201 and *0302 alleles.Semantic proximity Read ↗

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