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Article

Mapping protein-protein interactions between MutL and MutH by cross-linking.

The Journal of biological chemistry - 19 Nov 2004

Giron-Monzon Luis, Manelyte Laura, Ahrends Robert, Kirsch Dieter, Spengler Bernhard, Friedhoff Peter

Abstract excerpt

Strand discrimination in Escherichia coli DNA mismatch repair requires the activation of the endonuclease MutH by MutL. There is evidence that MutH binds to the N-terminal domain of MutL in an ATP-dependent manner; however, the interaction sites and the molecular mechanism of MutH activation have not yet been determined. We used a combination of site-directed mutagenesis and site-specific cross-linking to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15371440
DOI: 10.1074/jbc.M409307200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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