Article
Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability.
DNA repair - 1 Oct 2013
Pillon Monica C, Dubinsky Michelle, Johnston Randal N, Liu Shu-Lin, Guarné Alba
Abstract excerpt
Mutator strains spontaneously arise in bacterial populations under stress in an attempt to increase evolutionary adaptation. Inactivation of the ubiquitous DNA mismatch repair pathway, whose normal function is to correct replication errors and hence increase replication fidelity, is often the cause of the mutator phenotype. One of the essential genes in this pathway, mutL, includes a short tandem repeat that is...
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