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Article

MutL-catalyzed ATP hydrolysis is required at a post-UvrD loading step in methyl-directed mismatch repair.

The Journal of biological chemistry - 21 Jul 2006

Robertson Adam B, Pattishall Steven R, Gibbons Erin A, Matson Steven W

Abstract excerpt

Methyl-directed mismatch repair is a coordinated process that ensures replication fidelity and genome integrity by resolving base pair mismatches and insertion/deletion loops. This post-replicative event involves the activities of several proteins, many of which appear to be regulated by MutL. MutL interacts with and modulates the activities of MutS, MutH, UvrD, and perhaps other proteins. The purified protein...

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Identifiers

PMID: 16690604
DOI: 10.1074/jbc.M601604200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MutL-catalyzed ATP hydrolysis is required at a post-UvrD loading step in methyl-directed mismatch repair.PMID 16690604Read ↗

The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair.Semantic proximity Read ↗

Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repairSemantic proximity Read ↗

MutL: conducting the cell's response to mismatched and misaligned DNASemantic proximity Read ↗

The endonuclease domain of MutL interacts with the β sliding clamp.Semantic proximity Read ↗

Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability.Semantic proximity Read ↗

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair.Semantic proximity Read ↗

The alternating ATPase domains of MutS control DNA mismatch repair.Semantic proximity Read ↗

Contribution of Human Mlh1 and Pms2 ATPase Activities to DNA Mismatch RepairSemantic proximity Read ↗

Wot the 'L-Does MutL do?Semantic proximity Read ↗

Mapping protein-protein interactions between MutL and MutH by cross-linking.Semantic proximity Read ↗

Mechanism of MutS searching for DNA mismatches and signaling repair.Semantic proximity Read ↗

Involvement of the beta clamp in methyl-directed mismatch repair in vitro.Semantic proximity Read ↗

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