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Article

The function of Asp70, Glu77 and Lys79 in the Escherichia coli MutH protein.

Nucleic acids research - 1 Feb 2002

Wu Te-hui, Loh Tamalette, Marinus M G

Abstract excerpt

The MutH protein, which is part of the Dam-directed mismatch repair system of Escherichia coli, introduces nicks in the unmethylated strand of a hemi-methylated DNA duplex. The latent endonuclease activity of MutH is activated by interaction with MutL, another member of the repair system. The crystal structure of MutH suggested that the active site residues include Asp70, Glu77 and Lys79, which are located at the...

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Identifiers

PMID: 11809896
DOI: 10.1093/nar/30.3.818
PMCID: PMC100293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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