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Article

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair.

The EMBO journal - 27 Oct 2004

Guarné Alba, Ramon-Maiques Santiago, Wolff Erika M, Ghirlando Rodolfo, Hu Xiaojian, Miller Jeffrey H, Yang Wei

Abstract excerpt

MutL assists the mismatch recognition protein MutS to initiate and coordinate mismatch repair in species ranging from bacteria to humans. The MutL N-terminal ATPase domain is highly conserved, but the C-terminal region shares little sequence similarity among MutL homologs. We report here the crystal structure of the Escherichia coli MutL C-terminal dimerization domain and the likelihood of its conservation among...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15470502
DOI: 10.1038/sj.emboj.7600412
PMCID: PMC524388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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