Article
Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 1998
Sharma P, Hingorani A, Jia H, Ashby M, Hopper R, Clayton D, Brown M J
Abstract excerpt
Despite advances in the understanding of monogenic hypertensive disorders, the genetic contribution to essential hypertension has yet to be elucidated. The position of tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis renders it a candidate gene for the etiology...
Topics
- Adult
- Aged
- Blood Pressure
- Case-Control Studies
- Catecholamines
- Female
- Gene Frequency
- Genotype
- Humans
- Hypertension
- Male
- Microsatellite Repeats
- Middle Aged
- Nuclear Family
- Randomized Controlled Trials as Topic
- Reference Values
- Regression Analysis
- Risk Factors