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Article

Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.

Pharmacogenetics and genomics - 1 Apr 2011

Kohli Utkarsh, Hahn Maureen K, English Brett A, Sofowora Gbenga G, Muszkat Mordechai, Li Chun, Blakely Randy D, Stein C Michael, Kurnik Daniel

Abstract excerpt

BACKGROUND: The presynaptic norepinephrine transporter (NET) mediates synaptic clearance and recycling of norepinephrine. NET-deficient transgenic mice have elevated blood pressure (BP), heart rate, and catecholamine concentrations. However, the in-vivo effects of common NET variants on cardiovascular regulation at rest and during exercise are unknown. METHODS: We studied cardiovascular responses and plasma...

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Source

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Identifiers

PMID: 21412203
DOI: 10.1097/FPC.0b013e328344f63e
PMCID: PMC3065933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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