Article
Human heart rate: heritability of resting and stress values in twin pairs, and influence of genetic variation in the adrenergic pathway at a microribonucleic acid (microrna) motif in the 3'-UTR of cytochrome b561 [corrected].
Journal of the American College of Cardiology - 4 Feb 2014
Zhang Kuixing, Deacon Dekker C, Rao Fangwen, Schork Andrew J, Fung Maple M, Waalen Jill, Schork Nicholas J, Nievergelt Caroline M, Chi Neil C, O'Connor Daniel T
Abstract excerpt
OBJECTIVES: The goal of this study was to understand the role of genetic variation in the catecholamine biosynthetic pathway for control of human heart rate (HR). BACKGROUND: Human HR is an integrated cardiovascular trait predictive of morbidity and survival. Because the autonomic pathway exerts rapid control over the heart, we probed the role of heredity in the control of HR, focusing on a component of the...
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