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Article

Foxh1 is essential for development of the anterior heart field.

Developmental cell - 1 Sept 2004

von Both Ingo, Silvestri Cristoforo, Erdemir Tuba, Lickert Heiko, Walls Johnathon R, Henkelman R Mark, Rossant Janet, Harvey Richard P, Attisano Liliana, Wrana Jeffrey L

Abstract excerpt

The anterior heart field (AHF) mediates formation of the outflow tract (OFT) and right ventricle (RV) during looping morphogenesis of the heart. Foxh1 is a forkhead DNA binding transcription factor in the TGFbeta-Smad pathway. Here we demonstrate that Foxh1-/- mutant mouse embryos form a primitive heart tube, but fail to form OFT and RV and display loss of outer curvature markers of the future working myocardium,...

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Share to Embryo, Nonmammalian
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Homeobox Protein Nkx-2.5

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

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Source

Identifiers

PMID: 15363409
DOI: 10.1016/j.devcel.2004.07.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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