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Article

Fgf8is required for anterior heart field development

23 May 2006

Abstract excerpt

In the mouse embryo, the splanchnic mesodermal cells of the anterior heart field (AHF) migrate from the pharynx to contribute to the early myocardium of the outflow tract (OT) and right ventricle (RV). Recent studies have attempted to distinguish the AHF from other precardiac populations, and to determine the genetic and molecular mechanisms that regulate its development. Here, we have used an Fgf8lacZ allele to...

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Identifiers

PMID: 16720880
DOI: 10.1242/dev.02408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fgf8is required for anterior heart field developmentPMID 16720880Read ↗

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodelingSemantic proximity Read ↗

Foxh1 is essential for development of the anterior heart field.Semantic proximity Read ↗

Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar).Semantic proximity Read ↗

Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart fieldSemantic proximity Read ↗

Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.Semantic proximity Read ↗

<i>Fgf8</i>is required for pharyngeal arch and cardiovascular development in the mouseSemantic proximity Read ↗

Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferationSemantic proximity Read ↗

Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development.Semantic proximity Read ↗

Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and <i>nkx2.5</i> functionSemantic proximity Read ↗

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitorsSemantic proximity Read ↗

FGF signaling enforces cardiac chamber identity in the developing ventricleSemantic proximity Read ↗

Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.Semantic proximity Read ↗

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