Canonical Wnt signaling functions in second heart field to promote right ventricular growth.

doi:10.1073/pnas.0701212104

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Article

Canonical Wnt signaling functions in second heart field to promote right ventricular growth.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007

Ai Di, Fu Xueyao, Wang Jun, Lu Mei-Fang, Chen Li, Baldini Antonio, Klein William H, Martin James F

Abstract excerpt

The second heart field (SHF), progenitor cells that are initially sequestered outside the heart, migrates into the heart and gives rise to endocardium, myocardium, and smooth muscle. Because of its distinct developmental history, the SHF is likely subjected to different signals from that of the first heart field. Previous experiments revealed that canonical Wnt signaling negatively regulated first heart field...

Topics

Animals
Biomarkers
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins
Cell Lineage
Embryo, Mammalian
Gene Deletion
Gene Expression Regulation, Developmental
Heart Ventricles
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Phenotype

Signal Transduction

Stem Cells

Wnt Proteins

beta Catenin

Source

Open in PubMed Open full text

Identifiers

PMID: 17519332
DOI: 10.1073/pnas.0701212104
PMCID: PMC1890492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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