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Article

Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development.

Journal of the American Heart Association - 31 Dec 2015

Leung Carmen, Liu Yin, Lu Xiangru, Kim Mella, Drysdale Thomas A, Feng Qingping

Abstract excerpt

BACKGROUND: The small GTPase Rac1 regulates diverse cellular functions, including both apicobasal and planar cell polarity pathways; however, its role in cardiac outflow tract (OFT) development remains unknown. In the present study, we aimed to examine the role of Rac1 in the anterior second heart field (SHF) splanchnic mesoderm and subsequent OFT development during heart morphogenesis. METHODS AND RESULTS: Using...

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Identifiers

PMID: 26722124
DOI: 10.1161/JAHA.115.002508
PMCID: PMC4859369

Genes

SHF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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