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An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract

29 Sept 2023

Abstract excerpt

BACKGROUND: Conotruncal defects due to developmental abnormalities of the outflow tract (OFT) are an important cause of cyanotic congenital heart disease. Dysregulation of transcriptional programs tuned by NKX2-5 (NK2 homeobox 5), GATA6 (GATA binding protein 6), and TBX1 (T-box transcription factor 1) have been implicated in abnormal OFT morphogenesis. However, there remains no consensus on how these...

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PMID: 37772400
DOI: 10.1161/circulationaha.123.065700

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Research trail→

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An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow TractPMID 37772400Read ↗

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MEF2C regulates outflow tract alignment and transcriptional control of <i>Tdgf1</i>Semantic proximity Read ↗

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Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.Semantic proximity Read ↗

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