An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

doi:10.1016/j.cell.2007.01.042

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

Cell - 9 Mar 2007

Prall Owen W J, Menon Mary K, Solloway Mark J, Watanabe Yusuke, Zaffran Stéphane, Bajolle Fanny, Biben Christine, McBride Jim J, Robertson Bronwyn R, Chaulet Hervé, Stennard Fiona A, Wise Natalie, Schaft Daniel, Wolstein Orit, Furtado Milena B, Shiratori Hidetaka, Chien Kenneth R, Hamada Hiroshi, Black Brian L, Saga Yumiko, Robertson Elizabeth J, Buckingham Margaret E, Harvey Richard P

Abstract excerpt

During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In the cardiac fields of Nkx2-5 mutants, genes controlling cardiac specification (including Bmp2) and maintenance of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Proteins

Share to Feedback, Physiological

Share to Heart

Share to Homeobox Protein Nkx-2.5

Share to LIM-Homeodomain Proteins

Share to Multipotent Stem Cells

Share to Smad1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 17350578
DOI: 10.1016/j.cell.2007.01.042
PMCID: PMC2092439

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.PMID 17350578Read ↗

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.Semantic proximity Read ↗

Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.Semantic proximity Read ↗

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseasesSemantic proximity Read ↗

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract.Semantic proximity Read ↗

Nkx genes are essential for maintenance of ventricular identity.Semantic proximity Read ↗

Foxh1 is essential for development of the anterior heart field.Semantic proximity Read ↗

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.Semantic proximity Read ↗

A molecular and genetic outline of cardiac morphogenesisSemantic proximity Read ↗

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.Semantic proximity Read ↗

Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart fieldSemantic proximity Read ↗

Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5.Semantic proximity Read ↗

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.