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Article

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling

23 May 2006

Abstract excerpt

Fibroblast growth factor 8 (Fgf8) is a secreted signaling protein expressed in numerous temporospatial domains that are potentially relevant to cardiovascular development. However, the pathogenesis of complex cardiac and outflow tract defects observed in Fgf8-deficient mice, and the specific source(s) of Fgf8 required for outflow tract formation and subsequent remodeling are unknown. A detailed examination of the...

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PMID: 16720879
DOI: 10.1242/dev.02367

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