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Article

<i>Mef2c</i>is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development

15 Jul 2004

Abstract excerpt

The vertebrate heart forms initially as a linear tube derived from a primary heart field in the lateral mesoderm. Recent studies in mouse and chick have demonstrated that the outflow tract and right ventricle originate from a separate source of mesoderm that is anterior to the primary heart field. The discovery of this anterior, or secondary, heart field has led to a greater understanding of the morphogenetic...

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PMID: 15253934
DOI: 10.1242/dev.01256

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Related research

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Research trail→

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<i>Mef2c</i>is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic developmentPMID 15253934Read ↗

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heartSemantic proximity Read ↗

MEF2C regulates outflow tract alignment and transcriptional control of <i>Tdgf1</i>Semantic proximity Read ↗

GATA4 Is a Direct Transcriptional Activator of <i>Cyclin D2</i> and <i>Cdk4</i> and Is Required for Cardiomyocyte Proliferation in Anterior Heart Field-Derived MyocardiumSemantic proximity Read ↗

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodelingSemantic proximity Read ↗

Foxh1 is essential for development of the anterior heart field.Semantic proximity Read ↗

Isl2b regulates anterior second heart field development in zebrafishSemantic proximity Read ↗

ISL1 Directly Regulates FGF10 Transcription during Human Cardiac Outflow FormationSemantic proximity Read ↗

MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field.Semantic proximity Read ↗

The outflow tract of the heart is recruited from a novel heart-forming field.Semantic proximity Read ↗

A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac fieldSemantic proximity Read ↗

Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiationSemantic proximity Read ↗

The mesodermal source of fibronectin is required for heart morphogenesis and cardiac outflow tract elongation by regulating cell shape, polarity, and mechanotransduction in the second heart fieldSemantic proximity Read ↗

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