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Article

Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter.

The Journal of biological chemistry - 26 Nov 2004

Meinild Anne-Kristine, Sitte Harald H, Gether Ulrik

Abstract excerpt

Binding of Zn(2+) to an endogenous binding site in the dopamine transporter (DAT) leads to inhibition of dopamine (DA) uptake and enhancement of carrier-mediated substrate efflux. To elucidate the molecular mechanism for this dual effect, we expressed the DAT and selected mutants in Xenopus laevis oocytes and applied the two-electrode voltage clamp technique together with substrate flux studies employing...

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Identifiers

PMID: 15358780
DOI: 10.1074/jbc.M407660200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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