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Article

Dopamine directly modulates GABAA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Feb 2015

Hoerbelt Paul, Lindsley Tara A, Fleck Mark W

Abstract excerpt

Dopamine is a critical neuromodulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates. The present study demonstrates that dopamine (0.1-10 mm) exerts novel, opposing effects on different populations of mammalian (rat) GABAA receptors. Using whole-cell patch-clamp electrophysiology, we observed direct dopamine-mediated inhibition of tonic-level (1 μm) GABA-evoked currents in...

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Identifiers

PMID: 25716851
DOI: 10.1523/JNEUROSCI.4390-14.2015
PMCID: PMC6605556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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