Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor.

doi:10.1016/0896-6273(93)90209-a

Back to search

Article

Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor.

Neuron - 1 May 1993

Hollmann M, Boulter J, Maron C, Beasley L, Sullivan J, Pecht G, Heinemann S

Abstract excerpt

We have determined the gene structure for the NMDA receptor subunit gene NMDAR1. We found eight splice variants that arise from different combinations of a single 5' terminal exon insertion and three different 3' terminal exon deletions, relative to NMDAR1. We analyzed the modulation by Zn2+ of c...

Topics

Animals
Base Sequence
Cations
DNA
Drug Synergism
Electric Conductivity
Exons
Gene Deletion
Gene Expression
Genetic Variation
Introns
Molecular Sequence Data
Oocytes
RNA
RNA Splicing
RNA, Complementary
Rats
Receptors, N-Methyl-D-Aspartate

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.