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Article

Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter.

The Journal of biological chemistry - 19 Apr 2002

Borre Lars, Kavanaugh Michael P, Kanner Baruch I

Abstract excerpt

In the brain, the neurotransmitter glutamate is removed from the synaptic cleft by (Na(+) + K(+))-coupled transporters by an electrogenic process. Moreover, these transporters mediate a sodium- and glutamate-dependent uncoupled chloride conductance. In contrast to the wild type, the uptake of radiolabeled substrate by the I421C mutant is inhibited by the membrane-impermeant...

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PMID: 11823462
DOI: 10.1074/jbc.M110861200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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