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Article

A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter.

The Journal of biological chemistry - 12 Dec 2014

Pedersen Anders V, Andreassen Thorvald F, Loland Claus J

Abstract excerpt

Neurotransmitter transporters play an important role in termination of synaptic transmission by mediating reuptake of neurotransmitter, but the molecular processes behind translocation are still unclear. The crystal structures of the bacterial homologue, LeuT, provided valuable insight into the structural and dynamic requirements for substrate transport. These structures support the existence of gating domains...

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Identifiers

PMID: 25339174
DOI: 10.1074/jbc.M114.586982
PMCID: PMC4263896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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