Article
Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
The Journal of biological chemistry - 4 Jun 2010
Tao Zhen, Rosental Noa, Kanner Baruch I, Gameiro Armanda, Mwaura Juddy, Grewer Christof
Abstract excerpt
The glutamate transporter excitatory amino acid carrier 1 (EAAC1) catalyzes the co-transport of three Na(+) ions, one H(+) ion, and one glutamate molecule into the cell, in exchange for one K(+) ion. Na(+) binding to the glutamate-free form of the transporter generates a high affinity binding site for glutamate and is thus required for transport. Moreover, sodium binding to the transporters induces a basal anion...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.