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Article

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

Molecular pharmacology - 1 Mar 2009

Guptaroy Bipasha, Zhang Minjia, Bowton Erica, Binda Francesca, Shi Lei, Weinstein Harel, Galli Aurelio, Javitch Jonathan A, Neubig Richard R, Gnegy Margaret E

Abstract excerpt

The human dopamine transporter (hDAT) regulates synaptic dopamine (DA) levels and is the site of action of abused and therapeutic drugs. Here we study the effect of a threonine residue (Thr62 in hDAT) that is highly conserved within a canonical phosphorylation site (RETW) in the juxtamembrane N-terminal region of monoamine transporters. In stably transfected human embryonic kidney 293T cells, expression of...

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Identifiers

PMID: 19098122
DOI: 10.1124/mol.108.048744
PMCID: PMC2684905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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