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Article

Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.

The Journal of biological chemistry - 25 Dec 2015

Li Yang, Hasenhuetl Peter S, Schicker Klaus, Sitte Harald H, Freissmuth Michael, Sandtner Walter

Abstract excerpt

The dopamine transporter shapes dopaminergic neurotransmission by clearing extracellular dopamine and by replenishing vesicular stores. The dopamine transporter carries an endogenous binding site for Zn(2+), but the nature of the Zn(2+)-dependent modulation has remained elusive: both, inhibition and stimulation of DAT have been reported. Here, we exploited the high time resolution of patch-clamp recordings to...

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Identifiers

PMID: 26504078
DOI: 10.1074/jbc.M115.688275
PMCID: PMC4692231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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