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Article

Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.

The Journal of biological chemistry - 13 Feb 2004

Chen Nianhang, Rickey Judy, Berfield Janet L, Reith Maarten E A

Abstract excerpt

The present study elucidated the role of aspartate 345, a residue conserved in the third intracellular loop of all Na+/Cl(-)-dependent neurotransmitter transporters, in conformational changes of the dopamine (DA) transporter. Asparagine substitution (D345N) resulted in near normal transporter expression on the cell surface but caused extremely low Vmax and Km values for DA uptake, converted the inhibitory effect...

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Identifiers

PMID: 14660644
DOI: 10.1074/jbc.M306294200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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