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Article

The role of zinc ions in reverse transport mediated by monoamine transporters.

The Journal of biological chemistry - 14 Jun 2002

Scholze Petra, Nørregaard Lene, Singer Ernst A, Freissmuth Michael, Gether Ulrik, Sitte Harald H

Abstract excerpt

The human dopamine transporter (hDAT) contains an endogenous high affinity Zn2+ binding site with three coordinating residues on its extracellular face (His193, His375, and Glu396). Upon binding to this site, Zn2+ causes inhibition of [3H]1-methyl-4-phenylpyridinium ([3H]MPP+) uptake. We investigated the effect of Zn2+ on outward transport by superfusing hDAT-expressing HEK-293 cells preloaded with [3H]MPP+....

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PMID: 11940571
DOI: 10.1074/jbc.M112265200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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