Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human macrophages.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2004

Rydberg Ellen Knutsen, Krettek Alexandra, Ullström Christina, Ekström Karin, Svensson Per-Arne, Carlsson Lena M S, Jönsson-Rylander Ann-Cathrine, Hansson Göran I, McPheat William, Wiklund Olov, Ohlsson Bertil G, Hultén Lillemor Mattsson

Abstract excerpt

OBJECTIVE: Macrophage-mediated oxidation of low-density lipoprotein (LDL) by enzymes, such as the lipoxygenases, is considered of major importance for the formation of oxidized LDL during atherogenesis. Macrophages have been identified in hypoxic areas in atherosclerotic plaques. METHODS AND RESULTS: To investigate the role of hypoxia in macrophage-mediated LDL oxidation, we incubated human monocyte-derived...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Arachidonate 15-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arteriosclerosis

Share to Carotid Arteries

Share to Enzyme Activation

Share to Hypoxia

Share to Lipoproteins, LDL

Share to Oxidation-Reduction

Source

Identifiers

PMID: 15358603
DOI: 10.1161/01.ATV.0000144951.08072.0b

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human macrophages.PMID 15358603Read ↗

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.Semantic proximity Read ↗

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.Semantic proximity Read ↗

Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.Semantic proximity Read ↗

Hypoxia-Induced Gene Expression in Human MacrophagesSemantic proximity Read ↗

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of Atherosclerosis.Semantic proximity Read ↗

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient miceSemantic proximity Read ↗

Viral vector-mediated 12/15-lipoxygenase overexpression in vascular smooth muscle cells enhances inflammatory gene expression and migration.Semantic proximity Read ↗

15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness.Semantic proximity Read ↗

15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged swordSemantic proximity Read ↗

HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages.Semantic proximity Read ↗

Selective Interleukin-12 Synthesis Defect in 12/15-Lipoxygenase-deficient Macrophages Associated with Reduced Atherosclerosis in a Mouse Model of Familial HypercholesterolemiaSemantic proximity Read ↗

Association of polymorphisms in the ALOX15B gene with coronary artery disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.