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Article

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice

1 Jun 1999

Abstract excerpt

Atherosclerosis may be viewed as an inflammatory disease process that includes early oxidative modification of LDLs, leading to foam cell formation. This "oxidation hypothesis" has gained general acceptance in recent years, and evidence for the role of lipoxygenases in initiation of, or participation in, the oxidative process is accumulating. However, the relative contribution of macrophage-expressed...

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Share to Antioxidant Activity and Oxidative Stress
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PMID: 10359569
DOI: 10.1172/jci5897

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