Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness.

Human genetics - 1 Jun 2008

McCaskie Pamela A, Beilby John P, Hung Joseph, Chapman Caroline M L, McQuillan Brendan M, Powell Brenda L, Thompson Peter L, Palmer Lyle J

Abstract excerpt

The major underlying cause of CHD is atherosclerosis, and oxidised LDL is known to play an important role in its development. We examined the role of three single nucleotide polymorphisms (SNPs) in the 15-lipoxygenase gene (ALOX15), in atherosclerosis. We genotyped three SNPs in the ALOX15 promoter in two Western Australian samples-1,111 community-based individuals and 556 with CHD. SNPs and haplotypes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 15-Lipoxygenase
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carotid Arteries

Share to Carotid Artery Diseases

Share to Case-Control Studies

Share to Cross-Sectional Studies

Share to Haplotypes

Share to Tunica Intima

Source

Identifiers

PMID: 18392641
DOI: 10.1007/s00439-008-0496-6

Genes

ALOX15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness.PMID 18392641Read ↗

Association of polymorphisms in the ALOX15B gene with coronary artery disease.Semantic proximity Read ↗

No association of two functional polymorphisms in human ALOX15 with myocardial infarction.Semantic proximity Read ↗

Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.Semantic proximity Read ↗

Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.Semantic proximity Read ↗

Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding protein.Semantic proximity Read ↗

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.Semantic proximity Read ↗

Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.Semantic proximity Read ↗

Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population.Semantic proximity Read ↗

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study.Semantic proximity Read ↗

5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.Semantic proximity Read ↗

5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia.Semantic proximity Read ↗

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.