Article
Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.
PloS one - 1 Jan 2014
Vijil Carolina, Hermansson Cecilia, Jeppsson Anders, Bergström Göran, Hultén Lillemor Mattsson
Abstract excerpt
Atherosclerotic cardiovascular diseases are the leading causes of morbidity and mortality worldwide. We have previously shown that arachidonate 15-lipoxygenase B (ALOX15B) is highly expressed in atherosclerotic carotid plaques, and elucidation of mechanisms downstream of activated lipoxygenases may be relevant to our understanding of the genesis of atherosclerotic diseases. We examined 120 carotid plaques from...
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