Article
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Spanbroek Rainer, Grabner Rolf, Lotzer Katharina, Hildner Markus, Urbach Anja, Ruhling Katharina, Moos Michael P W, Kaiser Brigitte, Cohnert Tina U, Wahlers Thorsten, Zieske Arthur, Plenz Gabriele, Robenek Horst, Salbach Peter, Kuhn Hartmut, Radmark Olof, Samuelsson Bengt, Habenicht Andreas J R
Abstract excerpt
Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte-type 15-lipoxygenase has been implicated to mediate this oxidation. In addition, the 5-lipoxygenase cascade leads to formation of leukotrienes, which exhibit strong proinflammatory activities in cardiovascular tissues. Here, we studied both lipoxygenase pathways in human...
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