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Article

Viral vector-mediated 12/15-lipoxygenase overexpression in vascular smooth muscle cells enhances inflammatory gene expression and migration.

Journal of vascular research - 1 Jan 2008

Dwarakanath Roopashree S, Sahar Saurabh, Lanting Linda, Wang Nanping, Stemerman Michael B, Natarajan Rama, Reddy Marpadga A

Abstract excerpt

Increased expression and activity of 12/15-lipoxygenase (12/15-LO) in vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetes and vascular complications. However, the consequences of 12/15-LO overexpression for VSMC migration and inflammatory gene expression are not known. In this study, 12/15-LO was overexpressed using adeno- and baculoviral vectors in human VSMC (HVSMCs) and...

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Identifiers

PMID: 17943024
DOI: 10.1159/000109966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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