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Article

HSF1 blockade-induced tumor thermotolerance abolishment is mediated by JNK-dependent caspase-3 activation.

Biochemical and biophysical research communications - 27 Aug 2004

Wang Jin-Hui, Yao Ming-Zhong, Zhang Zi-Lai, Zhang Yan-Hong, Wang Yi-Gang, Liu Xin-Yuan

Abstract excerpt

We previously blocked the heat shock transcription factor 1 function with a dominant-negative mutant (mHSF1) in breast cancer cell line Bcap37, and found that mHSF1 sensitizes Bcap37 cells to hyperthermia by promoting the apoptotic process. Here we studied the mechanism of this abolishing process...

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Source

Identifiers

PMID: 15358168
DOI: 10.1016/j.bbrc.2004.07.018

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15358168-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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