Article
Neutralization of HSF1 in cells from PIK3CA-related overgrowth spectrum patients blocks abnormal proliferation.
Biochemical and biophysical research communications - 24 Sept 2020
Da Costa Romain, De Almeida Steven, Chevarin Martin, Hadj-Rabia Smail, Leclerc-Mercier Stéphanie, Thauvin-Robinet Christel, Garrido Carmen, Faivre Laurence, Vabres Pierre, Duplomb Laurence, Jego Gaëtan
Abstract excerpt
PIK3CA-related overgrowth spectrum is caused by mosaicism mutations in the PIK3CA gene. These mutations, which are also observed in various types of cancer, lead to a constitutive activation of the PI3K/AKT/mTOR pathway, increasing cell proliferation. Heat shock transcription factor 1 (HSF1) is the major stress-responsive transcription factor. Recent findings indicate that AKT phosphorylates and activates HSF1...
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