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Article

Overexpression of Heat Shock Transcription Factor 1 enhances the resistance of melanoma cells to doxorubicin and paclitaxel.

BMC cancer - 29 Oct 2013

Vydra Natalia, Toma Agnieszka, Glowala-Kosinska Magdalena, Gogler-Piglowska Agnieszka, Widlak Wieslawa

Abstract excerpt

BACKGROUND: Heat Shock Transcription Factor 1 (HSF1) is activated under stress conditions. In turn, it induces expression of Heat Shock Proteins (HSPs), which are well-known regulators of protein homeostasis. Elevated levels of HSF1 and HSPs were observed in many types of tumors. The aim of the present study was to determine whether HSF1 could have an effect on the survival of cancer cells treated with...

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Source

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Identifiers

PMID: 24165036
DOI: 10.1186/1471-2407-13-504
PMCID: PMC4231344

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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