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Article

Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer.

Cancer gene therapy - 1 Jan 2004

Ma Nancy, Szmitko Paul, Brade Anthony, Chu Isabel, Lo Alex, Woodgett Jim, Klamut Henry, Liu Fei-Fei

Abstract excerpt

We have previously demonstrated that protein kinase B (PKB) is a mediator of heat-induced apoptosis for human breast cancer cells. To investigate the therapeutic potential of abrogating the function of this important survival protein, a novel replication-deficient adenovirus was constructed, wherein a mutant, kinase-inactive PKB gene (AAA) was inserted downstream of the CMV promoter. Two human breast cancer cell...

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Identifiers

PMID: 14681726
DOI: 10.1038/sj.cgt.7700655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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