Article
Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.
Breast cancer research and treatment - 1 Feb 2003
Xia Wenle, Hardy Lys, Liu Leihua, Zhao Sumin, Goodman Mark, Voellmy Richard, Spector Neil L
Abstract excerpt
Most cancer therapies, including chemotherapy, kill tumor cells by inducing apoptosis. Consequently, the propensity of tumor cells to evade apoptotic signals contributes to therapeutic resistance. Here we show that breast cancer cells exhibiting a highly resistant phenotype undergo apoptosis when exposed to concurrent heat shock and H7, a potent serine/threonine kinase inhibitor. The anti-tumor effects of this...
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