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Article

Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2004

Höflinger Sonja, Kesavan Kamala, Fuxa Martin, Hutter Caroline, Heavey Barry, Radtke Freddy, Busslinger Meinrad

Abstract excerpt

Signaling through the Notch1 receptor is essential for T cell development in the thymus. Stromal OP9 cells ectopically expressing the Notch ligand Delta-like1 mimic the thymic environment by inducing hemopoietic stem cells to undergo in vitro T cell development. Notch1 is also expressed on Pax5-/- pro-B cells, which are clonable lymphoid progenitors with a latent myeloid potential. In this study, we demonstrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15356142
DOI: 10.4049/jimmunol.173.6.3935

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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