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Article

T cell development from kit-negative progenitors in the Foxn1Delta/Delta mutant thymus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008

Xiao Shiyun, Su Dong-ming, Manley Nancy R

Abstract excerpt

Foxn1Delta is a hypomorphic allele of the nude gene that causes arrested thymic epithelial cell differentiation and abnormal thymic architecture lacking cortical and medullary domains. T cells develop in the Foxn1Delta/Delta adult thymus to the double- and single-positive stages, but in the apparent absence of double-negative 3 (DN3) cells; however, DN3 cells are present in the fetal thymus. To investigate the...

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Source

Identifiers

PMID: 18178831
DOI: 10.4049/jimmunol.180.2.914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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