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Article

PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision.

Cellular & molecular immunology - 1 Sept 2019

Wang Ke, Zhang Xinwei, Wang Yifan, Jin Gaowen, Li Mingyang, Zhang Shusong, Hao Jie, Jin Rong, Huang Xiaojun, Wu Hounan, Zhang Jun, Chen Yingyu, Ge Qing

Abstract excerpt

Invariant natural killer T1 (iNKT1) cells are characterized by the preferential expression of T-box transcription factor T-bet (encoded by Tbx21) and the production of cytokine IFN-γ, but the relationship between the developmental process and iNKT1 lineage diversification in the thymus remains elusive. We report in the present study a crucial role of programmed cell death 5 (PDCD5) in iNKT cell terminal...

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Identifiers

PMID: 29921968
DOI: 10.1038/s41423-018-0059-2
PMCID: PMC6804728

Genes

PDCD5
TOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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