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Article

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.

The Journal of experimental medicine - 29 Jun 2015

Ungerbäck Jonas, Åhsberg Josefine, Strid Tobias, Somasundaram Rajesh, Sigvardsson Mikael

Abstract excerpt

To investigate how transcription factor levels impact B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. Whereas combined reduction of Pax5 and Ebf1 had minimal impact on the development of the earliest CD19(+) progenitors, these cells displayed an increased T cell potential in vivo and in vitro. The alteration in lineage fate depended on a Notch1-mediated...

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Source

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Identifiers

PMID: 26056231
DOI: 10.1084/jem.20132100
PMCID: PMC4493409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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